ParkinsonFranceV1, Main, Exploration, bibRecord, 001848

Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients

Identifieur interne : 001848 ( Main/Exploration ); précédent : 001847; suivant : 001849

Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients

Auteurs : A. Eusebio [Royaume-Uni, France] ; W. Thevathasan [Royaume-Uni] ; L. Doyle Gaynor [Royaume-Uni] ; A. Pogosyan [Royaume-Uni] ; E. Bye [Royaume-Uni] ; T. Foltynie [Royaume-Uni] ; L. Zrinzo [Royaume-Uni] ; K. Ashkan [Royaume-Uni] ; T. Aziz [Royaume-Uni] ; P. Brown [Royaume-Uni]

Source :

Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 2011.

RBID : Pascal:11-0212925

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Homme, Stimulation cérébrale profonde.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Deep brain stimulation, Human, Nervous system diseases, Parkinson disease.

Abstract

Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides. Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V. Conclusion The findings suggest that DBS can suppress pathological 11-30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Human</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Homme</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides. Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V. Conclusion The findings suggest that DBS can suppress pathological 11-30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Oxfordshire</li>
<li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Londres</li>
<li>Marseille</li>
<li>Oxford</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A." last="Eusebio">A. Eusebio</name>
</region>
<name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K." last="Ashkan">K. Ashkan</name>
<name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T." last="Aziz">T. Aziz</name>
<name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name>
<name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P." last="Brown">P. Brown</name>
<name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E." last="Bye">E. Bye</name>
<name sortKey="Doyle Gaynor, L" sort="Doyle Gaynor, L" uniqKey="Doyle Gaynor L" first="L." last="Doyle Gaynor">L. Doyle Gaynor</name>
<name sortKey="Foltynie, T" sort="Foltynie, T" uniqKey="Foltynie T" first="T." last="Foltynie">T. Foltynie</name>
<name sortKey="Pogosyan, A" sort="Pogosyan, A" uniqKey="Pogosyan A" first="A." last="Pogosyan">A. Pogosyan</name>
<name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W." last="Thevathasan">W. Thevathasan</name>
<name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W." last="Thevathasan">W. Thevathasan</name>
<name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L." last="Zrinzo">L. Zrinzo</name>
</country>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A." last="Eusebio">A. Eusebio</name>
</region>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients

Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients

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